Hello. I took 500mg of naproxen two hours ago for a muscle/joint injury contracted in the gym. however, the naproxen isn't having much effect. Can I take one (or two) tablets of diclofenac sodium 50 mg now to alleviate pain or should I wait until the nap Aleve (naproxen) and Celebrex (celecoxib), a COX-2 inhibitor, are types of nonsteroidal anti-inflammatory drugs (NSAIDs) that block your body from producing certain natural hormones that cause inflammation. Celebrex causes less inflammation and ulcers of the digestive tract than do other NSAIDs. Aleve and Celebrex both treat pain and inflammation caused by many conditions. Specializes in Rheumatology. Diclofenac and Aleve (naproxen): Dear Jessi: Diclofenac is in the NSAIDs class of anti-inflammtory drugs and Aleve ( Naproxen) is also a NSAID. The risk for side effects with NSAIDs is high, such as stomach ulcers. I discourage patients from taking more than 1 type of NSAID together as side effects can be serious Acetaminophen is an excellent pain killer and fever reducer. It has less effect on inflammation (though still some) when compared to any of the NSAIDs. People respond differently to drugs, so use whichever works for you personally. If you follow the dosing instructions on the label, all four are safe. Cyclobenzaprine is a muscle relaxant that may be used short-term to treat muscle spasms caused by musculoskeletal conditions, in addition to rest and physical therapy. Sedation is a common side more. Naproxen is effective for the short-term relief of pain and inflammation associated with arthritis, gout, menstruation, and tendonitis; however Nonsteroidal anti-inflammatory drugs (NSAIDs) pain management algorithm. Proceed down the algorithm on the basis of pain control and risk factors. Ibuprofen and naproxen are recommended on the basis of extensive evidence supporting efficacy and safety. For management of chronic/persistent pain, administration of NSAIDs with long half-lives has Piroxicam. Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed more. Prescribed for Osteoarthritis, Pain, Frozen Shoulder, Rheumatoid Arthritis, Temporomandibular Joint Disorder. piroxicam may also Naproxen has an average rating of 6.9 out of 10 from a total of 677 ratings on Drugs.com. 60% of reviewers reported a positive effect, while 25% reported a negative effect. Prednisone has an average rating of 7.5 out of 10 from a total of 841 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 18% reported a negative effect. 3IJMs.